How to prove efficacy with the smallest number of patients?
Every patient we investigate, over and above those needed to “prove” our hypothesis, is wasted time and money but is also needlessly exposed to an unproven drug. However, we do work within constraints; statistical power calculations set our target.
In the special circumstances of adaptive trial design (ATD), we are able to manage the differing cohorts based on accumulating data to maximize the study of any individual patient. Equally, in ANY study (ATD or classical design), we should look to minimize overrun of recruitment, a major issue in large multicenter studies.
The on-demand eClinical platform Timaeus permits study managers real-time access to full, clean data sets at the touch of a button.
